Type of resistance | Mechanism |
Target resistance | Mutation—a new KIT or PDGFRα point mutation and protein activation |
KIT genomic amplification | Overexpression of the KIT oncoprotein, without a new point mutation |
Target modulation | Activation of an alternate receptor tyrosine kinase protein, accompanied by loss of KIT oncoprotein expression |
Functional resistance | KIT or PDGFRα activation, outside the juxtamembrane hotspot regions, in the absence of a secondary point mutation |